Biodefense Applications

MagnaBioSciences is determining the feasibility of a number of biodefense (BD) assays that have far reaching applications for the detection of BD agents.

Scientists have shown that the MICT® technology can be used in many of their existing handheld detection devices for BD agents. When used in this way, they have demonstrated superior sensitivity, speed and quantification. Staphylococcus Enterotoxin B (SEB) and Francisella tularensis are examples of BD agents for which the MICT® technology demonstrated significantly higher sensitivity than optically read devices.

 

Rapid detection of biological agents, such as SEB, becomes critical when there is a threat of attack producing an outbreak of an illness. In such occurrences, public health labs need to identify the causative agent as soon as possible to try and contain the outbreak.

 

The MICT® workflow typically involved when lateral flow rapid tests are used to screen for the presence of biological materials.

 

Evaluation Criteria

System Requirements

• Uses lithium battery
• Does not require water
• Does not require external air or gas
• Does not require an external vacuum source

Throughput of product

• Single sample detection 20 minutes or less
• 1 samples/batch or higher, adaptable for more samples/batch.
• Less than 100 µl volume needed per test for detection

Training/Speed/Manpower

• Very brief training required.
• Less than 5 minutes required for set up.
• 0-2 manual steps required for detection.

Re-use

• Device or system is intended for multiple uses.
• 0-2 solution or buffer used.
• 2 components.
• No cleaning required.

Maintenance

• 0-1 consumable or expandable needed.
• No service required.
• Expected life greater than 10 years.
• Less than 5 minute required for daily assurance procedures.

Transportation

• Approximately the size of a multi-meter.
• Less than 0.5 Kg.
• Shelf life between 1 and 3 years.

Ease of Use/Utility

• Can view results in real time.
• No centrifugation steps.
• No shaking or vortexing steps.
• System always able to interpret raw data or call a positive through internal software.
• Assay available and capable of detecting two or more biological agents or toxins within the same test.
• No additional pieces of equipment needed.

Signature

• No sounds produced that cannot be deactivated.
• Less that 200 BTUS generated.

Operational conditions

• Operated from 4 C to 37 C.
• Components must be stored at room temperature.
• Performance of device is not influenced by relative humidity.

Sensitivity

• 1-100 cfu per ml